Stimulated parotid salivary flow rate in patients with Down syndrome.
Identifieur interne : 000484 ( Main/Exploration ); précédent : 000483; suivant : 000485Stimulated parotid salivary flow rate in patients with Down syndrome.
Auteurs : Stella Chaushu [Israël] ; Adrian Becker ; Gabriel Chaushu ; Joseph ShapiraSource :
- Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry [ 0275-1879 ]
Descripteurs français
- KwdFr :
- Adolescent (MeSH), Adulte (MeSH), Adulte d'âge moyen (MeSH), Analyse de variance (MeSH), Débit sécrétoire (physiologie), Enfant (MeSH), Facteurs âges (MeSH), Femelle (MeSH), Glande parotide (métabolisme), Glande thyroide (physiologie), Hormones thyroïdiennes (usage thérapeutique), Humains (MeSH), Hypothyroïdie (physiopathologie), Hypothyroïdie (traitement médicamenteux), Institutionnalisation (MeSH), Mâle (MeSH), Salive (composition chimique), Salive (métabolisme), Syndrome de Down (physiopathologie), Études cas-témoins (MeSH).
- MESH :
- composition chimique : Salive.
- métabolisme : Glande parotide, Salive.
- physiologie : Débit sécrétoire, Glande thyroide.
- physiopathologie : Hypothyroïdie, Syndrome de Down.
- traitement médicamenteux : Hypothyroïdie.
- usage thérapeutique : Hormones thyroïdiennes.
- Adolescent, Adulte, Adulte d'âge moyen, Analyse de variance, Enfant, Facteurs âges, Femelle, Humains, Institutionnalisation, Mâle, Études cas-témoins.
English descriptors
- KwdEn :
- Adolescent (MeSH), Adult (MeSH), Age Factors (MeSH), Analysis of Variance (MeSH), Case-Control Studies (MeSH), Child (MeSH), Down Syndrome (physiopathology), Female (MeSH), Humans (MeSH), Hypothyroidism (drug therapy), Hypothyroidism (physiopathology), Institutionalization (MeSH), Male (MeSH), Middle Aged (MeSH), Parotid Gland (metabolism), Saliva (chemistry), Saliva (metabolism), Secretory Rate (physiology), Thyroid Gland (physiology), Thyroid Hormones (therapeutic use).
- MESH :
- chemical , therapeutic use : Thyroid Hormones.
- chemistry : Saliva.
- drug therapy : Hypothyroidism.
- metabolism : Parotid Gland, Saliva.
- physiology : Secretory Rate, Thyroid Gland.
- physiopathology : Down Syndrome, Hypothyroidism.
- Adolescent, Adult, Age Factors, Analysis of Variance, Case-Control Studies, Child, Female, Humans, Institutionalization, Male, Middle Aged.
Abstract
Saliva is essential for oral defense against infections. Decreased salivary secretion may result in increased dental caries, oral mucosal changes, an altered sense of taste, difficulty in swallowing, and oral pain. A review of the literature reveals sporadic and contradictory reports on the use of sialometry and sialochemistry to explain the role of saliva in the oral health and well-being of subjects with Down syndrome. The present study documents parotid gland saliva secretion at different ages in a group of subjects with Down syndrome. Saliva was collected from 39 patients 11 to 62 years old, by means of a parotid salivary gland cup and under standardized conditions of stimulated secretion. The rate of salivary secretion in the entire group of patients with Down syndrome was lower than that of healthy controls and lower in the older study group compared with the younger group. Institutionalized subjects or those living in hostel-like apartments had a lower secretion rate than those living at home. No difference in salivary flow was found between those patients with Down syndrome with normal thyroid output and those with hypothyroidism who were receiving replacement therapy. In a four-way ANOVA with flow as the dependent variable and Down syndrome, hypothyroidism, institutionalization, and age as factors, Down syndrome was found to be the only variable significantly related to flow (p = 0.017). Our findings indicate that stimulated parotid salivary hypofunction in Down syndrome subjects is mainly related to their genetic disorder.
DOI: 10.1111/j.1754-4505.2002.tb01208.x
PubMed: 12014860
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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xml:lang="fr"><term>Adolescent (MeSH)</term><term>Adulte (MeSH)</term><term>Adulte d'âge moyen (MeSH)</term><term>Analyse de variance (MeSH)</term><term>Débit sécrétoire (physiologie)</term><term>Enfant (MeSH)</term><term>Facteurs âges (MeSH)</term><term>Femelle (MeSH)</term><term>Glande parotide (métabolisme)</term><term>Glande thyroide (physiologie)</term><term>Hormones thyroïdiennes (usage thérapeutique)</term><term>Humains (MeSH)</term><term>Hypothyroïdie (physiopathologie)</term><term>Hypothyroïdie (traitement médicamenteux)</term><term>Institutionnalisation (MeSH)</term><term>Mâle (MeSH)</term><term>Salive (composition chimique)</term><term>Salive (métabolisme)</term><term>Syndrome de Down (physiopathologie)</term><term>Études cas-témoins (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Thyroid Hormones</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Saliva</term></keywords><keywords scheme="MESH" qualifier="composition chimique" xml:lang="fr"><term>Salive</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Hypothyroidism</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Parotid Gland</term><term>Saliva</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Glande parotide</term><term>Salive</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Débit sécrétoire</term><term>Glande thyroide</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Secretory Rate</term><term>Thyroid Gland</term></keywords><keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Hypothyroïdie</term><term>Syndrome de Down</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Down Syndrome</term><term>Hypothyroidism</term></keywords><keywords scheme="MESH" qualifier="traitement 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Decreased salivary secretion may result in increased dental caries, oral mucosal changes, an altered sense of taste, difficulty in swallowing, and oral pain. A review of the literature reveals sporadic and contradictory reports on the use of sialometry and sialochemistry to explain the role of saliva in the oral health and well-being of subjects with Down syndrome. The present study documents parotid gland saliva secretion at different ages in a group of subjects with Down syndrome. Saliva was collected from 39 patients 11 to 62 years old, by means of a parotid salivary gland cup and under standardized conditions of stimulated secretion. The rate of salivary secretion in the entire group of patients with Down syndrome was lower than that of healthy controls and lower in the older study group compared with the younger group. Institutionalized subjects or those living in hostel-like apartments had a lower secretion rate than those living at home. No difference in salivary flow was found between those patients with Down syndrome with normal thyroid output and those with hypothyroidism who were receiving replacement therapy. In a four-way ANOVA with flow as the dependent variable and Down syndrome, hypothyroidism, institutionalization, and age as factors, Down syndrome was found to be the only variable significantly related to flow (p = 0.017). Our findings indicate that stimulated parotid salivary hypofunction in Down syndrome subjects is mainly related to their genetic disorder.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">12014860</PMID><DateCompleted><Year>2002</Year><Month>08</Month><Day>02</Day></DateCompleted><DateRevised><Year>2019</Year><Month>10</Month><Day>25</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0275-1879</ISSN><JournalIssue CitedMedium="Print"><Volume>22</Volume><Issue>1</Issue><PubDate><MedlineDate>2002 Jan-Feb</MedlineDate></PubDate></JournalIssue><Title>Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry</Title><ISOAbbreviation>Spec Care Dentist</ISOAbbreviation></Journal><ArticleTitle>Stimulated parotid salivary flow rate in patients with Down syndrome.</ArticleTitle><Pagination><MedlinePgn>41-4</MedlinePgn></Pagination><Abstract><AbstractText>Saliva is essential for oral defense against infections. Decreased salivary secretion may result in increased dental caries, oral mucosal changes, an altered sense of taste, difficulty in swallowing, and oral pain. A review of the literature reveals sporadic and contradictory reports on the use of sialometry and sialochemistry to explain the role of saliva in the oral health and well-being of subjects with Down syndrome. The present study documents parotid gland saliva secretion at different ages in a group of subjects with Down syndrome. Saliva was collected from 39 patients 11 to 62 years old, by means of a parotid salivary gland cup and under standardized conditions of stimulated secretion. The rate of salivary secretion in the entire group of patients with Down syndrome was lower than that of healthy controls and lower in the older study group compared with the younger group. Institutionalized subjects or those living in hostel-like apartments had a lower secretion rate than those living at home. No difference in salivary flow was found between those patients with Down syndrome with normal thyroid output and those with hypothyroidism who were receiving replacement therapy. In a four-way ANOVA with flow as the dependent variable and Down syndrome, hypothyroidism, institutionalization, and age as factors, Down syndrome was found to be the only variable significantly related to flow (p = 0.017). Our findings indicate that stimulated parotid salivary hypofunction in Down syndrome subjects is mainly related to their genetic disorder.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Chaushu</LastName><ForeName>Stella</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Orthodontics, Hebrew University-Hadassah School of Dental Medicine, Jerusalem, Israel. drshaush@netvision.net.il</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Becker</LastName><ForeName>Adrian</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Chaushu</LastName><ForeName>Gabriel</ForeName><Initials>G</Initials></Author><Author ValidYN="Y"><LastName>Shapira</LastName><ForeName>Joseph</ForeName><Initials>J</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D003160">Comparative Study</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Spec Care Dentist</MedlineTA><NlmUniqueID>8103755</NlmUniqueID><ISSNLinking>0275-1879</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D013963">Thyroid Hormones</NameOfSubstance></Chemical></ChemicalList><CitationSubset>D</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000367" MajorTopicYN="N">Age Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000704" MajorTopicYN="N">Analysis of Variance</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016022" MajorTopicYN="N">Case-Control Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002648" MajorTopicYN="N">Child</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004314" MajorTopicYN="N">Down Syndrome</DescriptorName><QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007037" MajorTopicYN="N">Hypothyroidism</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName><QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007326" MajorTopicYN="N">Institutionalization</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010306" MajorTopicYN="N">Parotid Gland</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012463" MajorTopicYN="N">Saliva</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012636" MajorTopicYN="N">Secretory Rate</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013961" MajorTopicYN="N">Thyroid Gland</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013963" MajorTopicYN="N">Thyroid Hormones</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2002</Year><Month>5</Month><Day>17</Day><Hour>10</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2002</Year><Month>8</Month><Day>3</Day><Hour>10</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2002</Year><Month>5</Month><Day>17</Day><Hour>10</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">12014860</ArticleId><ArticleId IdType="doi">10.1111/j.1754-4505.2002.tb01208.x</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Israël</li></country></list><tree><noCountry><name sortKey="Becker, Adrian" sort="Becker, Adrian" uniqKey="Becker A" first="Adrian" last="Becker">Adrian Becker</name><name sortKey="Chaushu, Gabriel" sort="Chaushu, Gabriel" uniqKey="Chaushu G" first="Gabriel" last="Chaushu">Gabriel Chaushu</name><name sortKey="Shapira, Joseph" sort="Shapira, Joseph" uniqKey="Shapira J" first="Joseph" last="Shapira">Joseph Shapira</name></noCountry><country name="Israël"><noRegion><name sortKey="Chaushu, Stella" sort="Chaushu, Stella" uniqKey="Chaushu S" first="Stella" last="Chaushu">Stella Chaushu</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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